Archive for 'epilepsy'

The role of changes in ion concentrations in epilepsy remains unclear. It had been long known that increase of [K+]o (Hodgkin and Horovicz, 1959) and/or decrease of [Ca2+]o (Frankenhauser and Hodgkin, 1957) lead to neuronal hyperexcitability and possible epilepsy. But, in epilepsy, the exact mechanisms of the ionic changes, and the contributions of network dynamics remain to be clarified. Here we used multi electrode array (MEA) recordings combined with K-selective electrode and optical measurements from in vitro hippocampal ...