Our research on epileptic seizures prediction is awarded by grant from the National Institute of Neurological Disorders and Stroke

Epilepsy comprises a group of disorders of the brain characterized by the periodic and unpredictable occurrence of seizures. Reliable means of detecting changes which occur during the pre-seizure state could serve as a method of seizure prediction, a benchmark in epilepsy research. A fast optical signal that coincides with the actual onset of neural activity has been observed both in vitro and in vivo. Pre-seizure fast optical signal, characterized by a reduction in near-infrared (NIR) optical scattering, occurs seconds to ...

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Our research on sleep and memory consolidation is awarded by grant from the Office of Naval Research.

During slow-wave sleep, the cortex is decoupled from external inputs, and can be devoted to consolidating previously acquired labile memories into stable memories. Recently, memory replay has been demonstrated during sleep, and associated with characteristic oscillations, giving rise to the hypothesis that these may form the critical neural substrate of memory consolidation. However, these studies have mainly focused on the rat hippocampus; while replay has also been demonstrated in other structures and species, evidence remains sparse, especially concerning the specific ...

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Dynamics of high-frequency synchronization during seizures. Krishnan GP, Filatov G, Bazhenov M. J Neurophysiol. 2013 May;109(10):2423-37.

The role of changes in ion concentrations in epilepsy remains unclear. It had been long known that increase of [K+]o (Hodgkin and Horovicz, 1959) and/or decrease of [Ca2+]o (Frankenhauser and Hodgkin, 1957) lead to neuronal hyperexcitability and possible epilepsy. But, in epilepsy, the exact mechanisms of the ionic changes, and the contributions of network dynamics remain to be clarified. Here we used multi electrode array (MEA) recordings combined with K-selective electrode and optical measurements from in vitro hippocampal ...

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