Epilepsy comprises a group of disorders of the brain characterized by the periodic and unpredictable occurrence of seizures. Reliable means of detecting changes which occur during the pre-seizure state could serve as a method of seizure prediction, a benchmark in epilepsy research. A fast optical signal that coincides with the actual onset of neural activity has been observed both in vitro and in vivo. Pre-seizure fast optical signal, characterized by a reduction in near-infrared (NIR) optical scattering, occurs seconds to ...
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